Monitoring of a patient's vital signs in their home using some form of wearable technology is of increasing importance and interest. Preferably, patients should be able to operate the system and perform the measurements themselves in a comfortable, easy and reliable way. Until now, only heart rate and rhythm measurements, e.g. obtained from the electrocardiogram or photoplethysmogram, have been realized in a home care scenario. Particularly interesting for telemonitoring applications are the hemodynamic measures such as stroke volume, systolic heart phases, or the development of edemas. The relatively simple bioimpedance technique has a long research history and has proven useful to detect changes in these latter measures. In addition, the technique can be implemented in wearables, such as functional textiles. This chapter discusses the basics of bioimpedance measurements and provides insight into the technical and design challenges relevant for the development of system components based on our experience to date.