This Chapter presents a brief analysis of research and engineering directions in ground vehicle dynamics and system design for more than 100 past years. It is shown that peculiarities of vehicle motion and dynamics of vehicles were established as an applied science – vehicle dynamics. Steady motion and transient maneuvers, multi-body dynamics, non-linear and stochastic dynamics, terramechanics, vehicle operational properties and their multi-criterion optimization, computer simulation, analysis and optimal synthesis, various types of control, inverse and direct vehicle dynamics approach, open architecture-type and multi-domain systems – all these makes the milestones of developments over the past century. New research directions were formulated in this Chapter, including agile interaction between ground vehicles and severe environments.