Studying technology will often involve studying change – or in the perspective of this chapter should involve not just studying but also actively being involved with change. Your presence and the questions you ask shape the way people think and act and on the other hand their responses and your study of practice change the researchers perspective. For Techno-Anthropologist, this means that asking in specific ways about technology and having a focus on technology in the data collection and fieldwork will (should) influence what they see, the data they collect and their analysis – and also the way the informants think and the way people talk about practice and technology. The Techno-Anthropological researcher should be aware and actively use the potential for change in the empirical study of technology. In this chapter I exemplify and examine how and why change can be embraced and seen as an integral part of Techno-Anthropological studies in Health Informatics and beyond. This statement is supported through reflections on empirical examples, qualitative methods, and ethical and philosophical considerations on research and change. The chapter concludes that Techno-Anthropologists should actively consider and engage in the potential for change of the empirical studies of technology.