Novel imaging techniques are playing an increasing role in tumour characterisation, assessment and management. However, incorporating imaging data into clinical trials presents a number of challenges in terms of quality control, standardisation in data collection, interoperability of widely used archiving systems and extensibility of imaging software architectures. Additionally, currently available monolithic applications cannot fulfil the diverse and rapidly changing needs of the clinical imaging research community. This paper discusses the limitations of the current CCLG Remote Data Entry (RDE) system and introduces the prototype of an alternative modular system based on the Extensible Neuroimaging Archive Toolkit (XNAT). The modular nature of the presented prototype promotes incremental software evolution and allows for flexible system customisation to suit the needs of individual imaging centres.