Virtual Histology Intravascular Ultrasound (VH-IVUS) is a clinically available for visualizing color coded of coronary artery plaque. However, current VH-IVUS image processing techniques have not considered the combinations of features to identify vulnerable plaque. This paper presents a new method for classification of TCFA (thin-cap fibroatheromas) and Non-TCFA plaque based on combined features using the VH-IVUS images using support vector machine (SVM). The proposed method is applied to 546 in-vivo VH-IVUS images. Results proved the dominance of our proposed method with accuracy rates of 98.15% for TCFA.