The purpose of this paper is to present the approach and the development of a software application (“lexicons connecting” system) to correlate effectively and unambiguously the correspondence between the specialist medical vocabulary and the familiar medical vocabulary for the cardiovascular domain. To investigate the question, the idea, the design, and the implementation of such system will be described. To this end, firstly, a number of research methodologies will be examined including domain ontologies development, database design and implementation. Then, the following implementation methodology and its results are presented. Finally, an example of the application use will be depicted and future work will be briefly described.