This study investigates the oblique capacity of a drilled pile embedded in a marine ground containing methane hydrates using the distinct element method. Results indicate that the presence of methane hydrates significantly enhances the uplift and lateral capacity of the pile. The peak shaft resistance of the pile decreases with the decrease of the inclination angle of pile displacement due to de-bonding, while the residual shaft resistance increases as a result of increasing lateral earth pressure mobilized at large pile displacement. The uplift component of the oblique forces has detrimental effect on the lateral capacity of the pile. The oblique capacity of the pile can be empirically correlated to the inclination angle of the displacement of the pile head.