The paper develops an approach to information system adaptation supporting diversity and heterogeneity of users. The user perspective is handled from culture point of view. Cultures are layered and this structure can be used for starting with national cultures and deriving stereotypes. Culture is recognised as a multidimensional structure, in which national culture provides a basement for the behavioural variations of individuals in personal level. For information system development this layering covers three different perspectives: cultural stereotypes and user models, organisational models and technology models. We thus may develop a coherent information system perspective that supports adaptivity in multicultural information system applications.