The homeland security enterprise is entering a new stage in its evolution. Focus is shifting to considerations of all-hazards, while resources are becoming increasingly scarce due to the challenging budget environment. Therefore, partnerships of all types must be leveraged to ensure that resources are used in the most effective ways possible. As the National Coordinator for critical infrastructure protection and resilience activities, the U.S. Department of Homeland Security (DHS), National Protection and Programs Directorate, Office of Infrastructure Protection (NPPD/IP) has addressed this challenge by establishing a Critical Infrastructure Risk Management Enhancement Initiative (CIRMEI) and an associated Regional Initiative. These initiatives ensure that DHS and its partners are identifying risks to critical infrastructure, measuring program effectiveness in managing those risks, and aligning resources to develop and execute the tasks and activities that are most successful in addressing those risks. Through the establishment of a set of desired outcome statements and associated metrics, NPPD/IP is assessing critical infrastructure protection and resilience programs and activities; the results will inform programmatic investments. The Regional Initiative, a public and private sector outreach campaign that is part of CIRMEI, will leverage public-private partnerships to collect information from DHS partners that will be used to enhance delivery of regionally tailored capabilities in each geographic section of the United States. As DHS confronts the dynamic and ever-changing environment facing critical infrastructure, CIRMEI provides a defense for the expenditure of valuable monetary and human resources and strives to close identified gaps in risk management capabilities.