Hospitals have a symbolic, social and political value which contributes to build a community's sense of security and well-being. Despite this key role, many hospitals all over the world are located in moderate to high-risk areas and are vulnerable in case a disaster takes place. Hospital evacuation is a major concern and requires a large number of qualified personnel to intervene in a short time to transfer critical patients to safe areas. Medical students can provide an efficient solution to the problem. A group of medical students was trained through a dedicated disaster medicine course composed of three sessions (a medical, a psycho-social and a technical session). Students developed remarkable skills and became capable of cooperating with hospital personnel by applying basic rescue maneuvers during a hospital evacuation. Moreover, a mobile phone application was created in order to contact students quickly and provide them with information about the scenario in case an emergency occurs. A few drills were performed, too.