The adaptation of the 10x10 certificate program in health information systems for a Puerto Rican audience is described. The 10x10 program was initially developed in the USA by the Oregon Health Sciences University (OHSU), then adapted to Latin America by Hospital Italiano de Buenos Aires. Puerto Rico is in the intersection of the United States and Latin America, in terms of government, health care system, culture and language. Therefore, it seemed reasonable to re-adapt the program back to the USA, in Spanish, taking into account these facts and the experience of the team in delivering blended learning adapted to local needs. Forty professionals from Puerto Rico are currently taking the first version of the course, supported by the Regional Extension Center for Puerto Rico and the US Virgin Islands, and endorsed by the American Medical Informatics Association (AMIA).