The national e-prescription system of Greece was first introduced in 2010 and already covers more than 80% of all prescriptions prescribed today (more than 5 million per month). Its introduction provided a powerful tool for improving patient services and public health planning. The system is also already a valuable source of planning, control and transparency data for the Greek healthcare system. In addition, the experience from its application at national level in Greece has also shown that e-Prescription systems can also provide a very useful tool for better administrative control and for containing unnecessary expenditure related to medication use.