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Exposure of human skin to solar ultraviolet radiation both causes damage to skin cells and triggers signaling cascades that regulate cellular gene expression. Both effects may be mediated by reactive oxygen species (ROS) such as singlet oxygen and superoxide. In this chapter, the photochemical generation of ROS, the oxidation of biomolecules and activation of signaling cascades by ROS as well as the medical use of photooxidation reactions in photodynamic therapy will be briefly discussed.
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