ICT application in education has become one of the most attractive topic discussed in modern educational theory and practice. This paper try to verify the effect of ICT application in education, especially in development of students' advanced cognitive abilities, by confirmative experiments in online learning support system named PRIME. After data analysis, the paper gets the conclusions that the PRIME improves students' learning achievement by affect the students' advanced cognitive abilities, and the students' advanced cognitive abilities, as intermediate variables, play very important roles on the performances of students, where PRIME affects their learning.