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Cardiomyocyte deficiency is the leading cause of heart failure. The recent discovery of resident adult cardiac progenitor cells together with the rapid evolution of the stem cell research area have begun to re-evaluate the clinical relevance of regenerative cardiac therapies. Uncovering the developmental origins of adult cardiac progenitors, understanding how these populations are set aside and characterizing the molecular mechanisms regulating their fate during development are of crucial importance for regenerative medicine and will bring new insights into cardiac repair strategies.
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