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One of the greatest challenges in cell therapy is to deliver viable stem cells to injured tissues with a high engraftment efficiency. Some studies have shown that under physiological conditions, stem cells may be mobilized by cytokines or growth factors which allow them to leave their niche and home into peripheral tissues. To improve this phenomenon, recombinant proteins or pharmacological agents are now widely used. In this review we will focused on the three main types of circulating stem cells: hematopoietic stem cells, endothelial progenitor cells and mesenchymal stem cells.
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