Search
 
loader loading subjects...
cover
ROS-Induced Oscillations of Mitochondrial Transmembrane Potential in Cultured Rat Astocytes
Vsevolod Belusov, Linda Bambrik, Anatoly Starkov, Gary Fiskum, Vladimir Skulachev, Dmitry Zorov
55 - 59
NATO Science Series, I: Life and Behavioural Sciences
Volume 367: Free Radicals and Diseases: Gene Expression, Cellular Metabolism and Pathophysiology
Abstract

Cell death can be triggered by opening of the mitochondrial permeability transition pore (MPT). A recent study with cardiomyocytes revealed ROS-induced oscillations in mitochondrial membrane potential (DY) ascribed to the opening and closing of the MPT. In neurones, DY oscillations have been reported which appear not to be driven by the MPT. Here we describe oscillations in mitochondrial TMRE fluorescence in astrocytes that are enhanced by exposure to light and reduced by CSA, consistent with the involvement of the MPT in DY flickering.

$35.00 / €27.50 / £22.00
Add PDF to cart