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mtNOS: Regulation by Mitochondrial Membrane Potential
Tamara Zaobornyj, Laura B. Valdez
35 - 42
NATO Science Series, I: Life and Behavioural Sciences
Volume 367: Free Radicals and Diseases: Gene Expression, Cellular Metabolism and Pathophysiology
Abstract

The state 4-state 3 transition regulates NO release in coupled mitochondria, the rates were 40–50% lower in state 3 than in state 4. The rates of NO production by liver and kidney mitochondria were 1.3 and 0.7 nmol/min.mg protein in state 4, and 0.7 and 0.4 nmol/min.mg protein in state 3. The state 4-state 3 transition regulates NO production by the transition of mitochondrial membrane potential and not of intramitochondrial pH. Nitric oxide production was voltage dependent showing higher rates at higher mitochondrial membrane potentials.

$35.00 / €27.50 / £22.00
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