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Yeast is an established model in the studies of aging. Both replicative aging (limited capacity of budding) and chronologic aging (limited capacity to survive in the stationary culture) are studied in Saccharomyces cerevisiae Perhaps the most interesting aspect of these studies is the identification of genes affecting the cellular lifespan.
Oxidative stress is a factor in both replicative and chronologic aging. Yeast deficient in antioxidant and antioxidant enzymes show decreased replicative and chronologic lifespan while overexpression of some antioxidant proteins prolongs the lifespan.
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