In this chapter, bioinformatics techniques are used to gain some insights into the structure and function of a largely uncharacterised protein family called SAND. From a phylogenomics analysis, we determine SAND as a eukaryotic gene and show that a duplication event gave rise to two SAND genes in vertebrates. SAND was found to be absent from archea and bacteria. From a phylogenetic analysis, we characterise a number of subfamilies. With the use of multiple sequence alignments, we highlight amino acids and sequence motifs conserved in SAND proteins plus those invariant in subfamilies or taxonomical groups. In addition, we predict a secondary structure and solvent accessibility profile and carry out protein fold predictions for the SAND proteins.