Structural genomics requires that accurate atomic resolution protein structures are solved in high-throughput. The Northeast Structural Genomics Consortium (NESG), USA, has established a scalable platform for NMR-based structure determination, including protocols for rapid NMR data acquisition, semi-automated data processing, data analysis and structure calculation, and structure validation. The main features of this pipeline are discussed along with (i) recent methodological advances and (ii) perspectives for future improvements and expansion to larger bio-molecular systems.
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