RNA and DNA can adopt highly different conformations to facilitate protein or ligand binding. These conformational changes are significant, since they often are an essential part of nucleic acid function. As a result, there is ever increasing interest in studying dynamics of nucleic acids and their connection to function. Here, we review NMR methods, in both the solid and liquid states, to study nucleic acid dynamics, including relaxation, residual dipolar couplings and lineshape analysis.
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