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Synchrotron infrared microscopy exploits the so-called brightness (or brilliance) advantage of synchrotron radiation. The main characteristics of such a source, coupled with an infrared microscope, are reviewed. Several important applications in the biomedical field are summarized including drug effects on cancer cells, growth factor signaling in single cells, compositional changes in microdamaged bone, infectious prion protein structure in nervous tissues, human substantia nigra in Parkinson's disease and β-amyloid deposition in Alzheimer's disease.
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