The development of synchrotron radiation circular dichroism (SRCD) spectroscopy, which uses the intense light of a synchrotron beam, has greatly expanded the utility of circular dichroism (CD), enabling the measurement of lower wavelength data containing more electronic transitions and hence more structural information. Furthermore the higher signal-to-noise and the ability to do faster measurements facilitate high-throughput data collection using smaller samples. In general the good practice protocols required for conventional CD studies also apply to SRCD studies; however there are additional good practice issues unique to SRCD spectroscopy and these are covered in this chapter.