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Sample Preparation and Good Practice in Circular Dichroism Spectroscopy
Sharon M. Kelly, Nicholas C. Price
91 - 107
10.3233/978-1-60750-000-1-91
Advances in Biomedical Spectroscopy
Volume 1: Modern Techniques for Circular Dichroism and Synchrotron Radiation Circular Dichroism Spectroscopy
Abstract

This chapter aims to set out the guidelines for obtaining reliable CD data when studying molecules of biological interest. The main focus will be on the study of protein samples, but the points about sample purity and characterisation, attention to the solvent system employed, the proper use of the instrument and appropriate methods of data handling apply to all samples, whether they are small molecules, such as drugs or other ligands or macromolecules such as nucleic acids or their fragments. More details on most of these aspects are given in the review by Kelly et al. [1].

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