Low-energy neutrino physics and astrophysics has been one of the most active fields of particle physics research over the past two decades, achieving important and sometimes unexpected results, which have paved the way for a bright future of further exciting studies. The methods, the techniques and the technologies employed for the construction of the many experiments which acted as important players in this area of investigation have been crucial elements to reach the many accumulated physics successes. The topic covered in this review is, thus, the description of the main features of the set of methodologies at the basis of the design, construction and operation of low-energy neutrino detectors.