Radiation particles, besides their application to fundamental research, are widely used in all fields of science (medicine, material science, chemistry, etc.). Up to now the radiations were produced by sources like accelerators, X-ray tubes, radioactive materials with the well-known problems of costs, parameters and safety. In the last few years, following the development of lasers able to focus ultrashort high-intensity pulses onto targets, the generation of ionizing radiation by intense lasers have become possible. This paper focuses on the radiological protection aspects, mainly licensing requirements, prompt and residual radiation fields, shielding of produced radiations, shielding materials, radiation monitoring, determination of any environmental impact, and other specific operational requirements of an “accelerator facility”, that a project manager should take into account in designing a facility for laser-based accelerators.