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Energy landscapes of bimolecular binding and molecular modulators of protein-protein interactions
G. M. Verkhivker
253 - 271
10.3254/978-1-58603-792-5-253
Proceedings of the International School of Physics "Enrico Fermi"
Volume 165: Protein Folding and Drug Design
Abstract

1. Energy landscapes and molecular recognition; 2. Binding hot spots and convergent solutions at protein-protein interfaces; 3. Targeting P53-MDM2 interfaces with molecular modulators; 4. Materials and methods; 4.1. Structural analysis; 4.2. Hierarchical models of biomolecular recognition; 5.Results and discussion; 5.1. Conformational landscape of MDM2 and specific binding with small molecular mimics; 5.2. The energy landscape analysis of a hot spot at the consensus binding site of the constant fragment (Fc) of human immunoglobulin G.

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