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Molecular recognition through local elementary structures: Transferability of simple models to real proteins
R. A. Broglia, G. Tiana, D. Provasi, L. Sutto
85 - 113
10.3254/978-1-58603-792-5-85
Proceedings of the International School of Physics "Enrico Fermi"
Volume 165: Protein Folding and Drug Design
Abstract

1. Introduction; 2. The lattice model; 2.1 Inverse folding problem: the design of good folders; 2.2 Role of the different amino acids in the folding process; 2.3. Extension of the inverse folding strategy; 2.4. How many mutations can a designed protein tollerate?; 3. Hierarchical folding of a model protein; 4. Solving the protein folding problem in the case of a notional protein (three-step-strategy (3SS)); 5. Lattice model design of resistance proof, folding-inhibitor peptides; 6. Drug resistance; 7. Design and folding of dimeric proteins; 8. Conclusions

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