In many countries of the world for water supply in cities and settlements large borehole water intakes were installed and, as a result in these regions, a significant reduction in groundwater levels has occurred. In karst regions this activates land subsidence and other hazardous environmental effects. Karst is a hazardous engineering-geological process that can be especially disastrous for civil, industrial and hydrotechnical constructions. This article discusses the results of engineering-geological, hydrogeological and geophysical complex investigations that were carried out in the northern part of Syria, in the territory of Ras Al Ayn City. Karst processes have been activated during recent years in this area mainly because of human activities. A number of target maps has been drawn for the case study area including the zoning map of the karst risk and, according to the map, the city territory is divided into the three parts. The necessary engineering measures are proposed for ecological remediation of the studied area. The practical test of the proposed design method, developed for forecasting possible activation of karst phenomena, should be considered of especial importance. This proposed method for prognosis of land subsidence is recommended for use in similar physical-geological conditions.