A brain undergoing Traumatic Brain Injury (TBI) suffers damage to almost all areas, and the pattern of lesions reflects the forces on the skull at the moment of the trauma; different symptoms result after every single trauma. The common problem for those afflicted by TBI is how to overcome the sudden change in emotions and how to accept their new situation with memories in the body still corresponding to the time before the accident. Members of the Austrian Association of TBI suffering from TBI were questioned concerning their situation after TBI. The change in life affects personal capacities, family and work relationships, ability to work, and financial/social situation and results in a change in relationships with key people in their life. The burden of change is more important if the person was previously a strong, body-oriented person who had to define himself through a hierarchic system, e.g. military organisation. The TBI patient may feel a resulting emptiness in their life, inside and out, and has to reorient himself with a reduced brain capacity. Most people, the injured and families alike, feel a sense of loneliness after TBI. Caregivers and case managers are not skilled enough to deal with emptiness, reorientation, the mourning process and the issue of responsibilities resulting from medical, therapeutic and social consequences after TBI. Reorientation Syndrome is a considerable condition after each TBI that has to be respected to understand how to help TBI patients and their families successfully reintegrate into a functional life after TBI.