Traumatic Brain Injury (TBI) is often comorbid with psychiatric disturbances that impede patients' recovery and everyday functioning. We present two case studies of patients who exhibited psychiatric disorders after TBI. Both patients were included in psychiatric treatment for approximately one year without improvement in anxiety, depressive symptoms, and quality of life in everyday functioning, before we decided to apply biofeedback/neurofeedback (BFB/NFB) treatment as add-on therapy. Protocols of BFB/NFB treatment are described in the paper. BFB/NFB treatment showed clinical improvement in anxiety, depressive symptoms, and overall functioning, which was confirmed by psychophysiological measures and clinical scales, as well as by patients' subjective reports.