Traumatic Brain Injury (TBI) is extremely prevalent in the soldiers returning from Iraq and Afghanistan. Although some soldiers in the United States are currently being screened for TBI both before and after they are deployed, there are many factors that limit the validity of these screenings. For example, many soldiers are reluctant to “step up” because they are concerned that a positive screen will delay their return home. Additionally, many of the symptoms of mild TBI may not emerge until the soldiers have returned home and picked up the fabric of their former life. This paper will review an approach to screening for TBI, the Brain Injury Screening Questionnaire (BISQ). Additionally, the development, validity and research on the BISQ, as well as its potential diverse clinical applications, will be reviewed.