The intense growth of electrical energy production at nuclear power plants (NPP) results in the increasing generation of radionuclide gas-aerosol discharges (RGAD) to atmosphere and liquid radioactive discharges (LRD) into different water bodies. According to the observed Russian Federal Programme, 17 new nuclear reactors will be commissioned up to 2020 at the 7 currently operated NPPs. It is necessary to provide exclusive safety measures, particularly regarding the limiting of irradiation human organism doses (IHD). These IHDs must not exceed the 10 Micro Sievert level on every factor of response, that have based by the special homeland sanitary rules and instructions, corresponded to the international ones. We have collected and analyzed data on RGAD and LRD values for all 10 Russian NPPs during the last 13 years of their exploitation. The observed stable annual tendency of decreasing of these values has created a well-grounded scientific base for predicting the levels for each NPP in the future period of Program realization according to our developed methodology. The predicted RGAD and LRD levels have been used for IHD calculations on the special certified model information-simulation systems (developed in our Institute) through all possible ways and chains of radionuclide penetration into human organisms. For the most critical population group, namely fishermen, we have carried out conservative (maximum) IHD assessments. The obtained IHD values provide the permitted risk level less than 10⁻⁶ per year (i.e. one death per one million irradiated people). The radiation, created by every NPP under its future exploitation, will be less by 2-3 orders than the local natural radioactive background near NPP locations. Our consideration has a universal character and may be used for making decisions on some thematic problems of atomic energy.