A technique for revealing surface morphology of human cervical cancer cells has been developed to facilitate early diagnostics of pre-cancer and cancer cells under reflected light microscopy. The offered method was borrowed from optical microscopy of a solid state surface, in which the metallographic inverted microscopy (MIM) is usually used. Unlike commonly accepted transmitted light microscopy for biological applications, the MIM technique allows to reveal a morphology and topology of a biological cells surface without any treatment by chemicals (fixing, staining, drying, freezing et al). The MIM method was demonstrated by analysing fresh native smears from epithelium of uterine neck. MIM micrographs of 167 patients with diagnosed cervical cancer allow to visualise numerous the light reflective formations (LRF) on the cancer cells surface. It is supposed that LRF are connected with exocytosis on the cell membrane.
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