A regional environmental movement reaches across Palestinian, Israeli, and Jordanian political and geographic boundaries. This chapter describes the structure, outlook, achievements, and challenges of several regional environmental civil society initiatives that have been active since the 1990s: the water and environment department of the Israel Palestine Center for Research and Information, EcoPeace/Friends of the Earth Middle East, and the Arava Institute for Environmental Studies. Particular attention is paid to the challenge of frame alignment. Dominant nationalist discourses in the region do not align well with a discourse of a fragile ecosystem that requires robust regional institutions. On the other hand, a discourse of regional ecosystem fragility aligns well with the discourses of sustainable development and of a global and regional environmental crisis in which the Eastern Mediterranean will be particularly harshly impacted by climate change.