A comprehensive understanding of earthquake risks in urbanized regions requires an accurate assessment of both urban vulnerabilities and earthquake hazards. Socioeconomic risks associated with human-triggered earthquakes are often misconstrued and receive little scientific, legal, and public attention. However, more than 200 damaging earthquakes, associated with industrialization and urbanization, were documented since the 20th century. This type of geohazard has impacts on human security on a regional and national level. For example, the 1989 Newcastle earthquake caused 13 deaths and US$3.5 billion damage (in 1989). The monetary loss was equivalent to 3.4 percent of Australia’s national income (GDI) or 80 percent of Australia’s GDI per capita growth of the same year. This article provides an overview of global statistics of human-triggered earthquakes. It describes how geomechanical pollution due to large-scale geoengineering activities can advance the clock of earthquakes or trigger new seismic events. Lastly, defense-oriented strategies and tactics are described, including risk mitigation measures such as urban planning adaptations and seismic hazard mapping.