This paper offers a methodology for socio-ecological monitoring. It consists of high-sensitive indicator systems and a unified procedure for estimating the integral environmental condition with regard to the toxic-mutagenic background, and the general and genetic health of the population. It permits the definition of the integral criteria describing the ecological and genetic hazards for biota and human beings from the impact of mutagenic ecological factors. The paper shows a perspective of using a micro-nucleus test in the system of a socio-ecological monitoring in somatic cells of a person. This test also defines the general mutagenic background and the state of a human organism in the cytogenetic status.