Geographical Information Systems (GIS) have been found to be very useful in seismic hazard and risk assessment studies. GIS can be used to integrate vast amounts of data geographically, take the spatial distribution of phenomena into consideration and communicate the results graphically, performing analysis of complex mathematical models. The central part of Chisinau (6.3 km² site), capital of the Republic of Moldova, has been the case study in a project aimed at the assessment of vulnerability of buildings to seismic impact. The city is exposed to Vrancea earthquakes experiencing PGA ≅ 300 cm/s² for recurrence interval T = 475 yr [6]. Collection, classification and digitization into ArcView GIS format of the main characteristics of the subsoil, such as mean shear wave velocity, natural period of vibration and amplification factor, compilation of database for the existing structures, as well as construction of Digital Terrain Model (DTM), were performed. The final product is the GIS database and software module for purposes of evaluation of seismic damage to buildings. The incorporation of the amplification capacity of the soil through the direct utilization of the transfer function constructed on the base of geotechnical data, allows fast assessment of scenario seismic events and mapping of parameters of the ground motion (PGA, EPA, etc.). The existence of moderate-magnitude and blast records for the studied site, as well as databases of building damage, allow validation of the accepted techniques and methodologies for ground motion and damage simulations.