This paper demonstrates the institutional approach to drugs and drug related problems as well as drug prevention methods in Turkey. Drug related problems have many dimensions and each could affect and trigger each other. From production to trafficking, street level drug selling to drug usage, and narco-terror, drugs pose a significant threat to societies. Institutions play an important role to cope with those problems; however, different dimensions could be related to the responsibilities of different institutions. Institutional cooperation at the national and international level is an important way to overcome those problems. In the second part, this paper presents an example of national and international cooperation to reduce the problem of drugs in the society.