This chapter, after briefly outlining the main features of hazmat transportation and related risk, presents a risk-based approach for planning and managing the hazmat flows on road infrastructures. A dynamic hazmat vehicle routing problem at a sub regional scale is considered modelling transport risk on each link of the network. The considered hazmat routing problem has been stated as a multi-objective mathematical programming problem. The information used in order to pose this dynamic routing problem is relevant to the link risk, the network structure, and the current (and foreseen) hazmat and generic traffic incoming and outgoing the network. It is assumed that the decision maker is a Public Authority which has the responsibility of controlling and managing the road network and traffic flows. The main objective of the Authority is to equalize the risk on the overall network and to minimize the risk for all kinds of road infrastructure users. A territorial analysis has been performed to characterize each link according to the induced risk assessment. A case study relevant to the District of Cuneo, in Northern Italy, is presented to validate the applicability of the approach.