The purpose of the present study was to explore the acculturation patterns of immigrants in Greece in relation to their economic and psychological adaptation. The following research questions were examined: How do immigrants adapt to the host culture? How do they deal with the multiple pressures and challenges of “culture shock”? What is the relationship between acculturation strategies and the quality of adjustment? The sample consisted of 601 immigrants (43% women) from 35 nationalities who resided in urban and rural areas in the host country (mean length of stay: 8 years). Results indicated that levels of adaptation varied according to the cultural distance hypothesis, with immigrants from Europe and the Balkans doing better than immigrants from sub-Sahara African and Islamic countries. Most immigrants chose to integrate (46%); 21% assimilated; 25% were separated; and 8% reported an individualistic profile. Acculturation strategies were related to the quality of adaptation, i.e. integration and assimilation yielded the most positive outcomes and separation the most negative. Length of stay in the host country had an indirect effect on adaptation through the acculturation variables. Implications of findings for policy making are discussed.