Due to a decrease in physical activity, in particular lower limb amputees experience a decline in physical fitness. However, apart from many other beneficial effects of being more active, amputee individuals may obtain impressive advantages if they regularly exercise. Human body systems, in particular cardiovascular, muscle and bone, respiratory and nervous systems, may readily react and adapt to exercise in order to serve the increased demands. The human body supports the more active systems through several neuronal, hormonal, and metabolic regulations. These actions may improve and become stronger if the exercise is performed regularly. Moreover, several structural adaptive changes, especially in the cardiovascular and muscle system, appear as the exercise is repeated. The adaptation capacity of human systems is great when the amputee individual lives a more active life-style. The latter may be achieved either through having a more active daily life-style and/or participating in a sport team or activity organization, such as walking club and others. In this way, amputee individuals may obtain health promotions affecting both body and mind. Furthermore, other preventive health effects, in particular against chronic or age-related disorders such as diabetes, hypertension, cancer, and atherosclerosis, may naturally occur in the amputee body.