In the e-health domain, territorial emergencies represent dynamic, unpredictable and heterogeneous situations where software agents can be exploited in an effective way, thanks to their features of autonomy, reactivity, proactvity and sociality. In this chapter we discuss about the exploitation of agents in e-health and territorial-emergency situations, and we present UbiMedic, an agent-based system developed to provide services in the e-health field in general, which can be successfully exploited in emergency scenarios. In addition, we report some considerations that aim at being useful to developers that are going to consider agents to build applications in the field of e-health.