As the development of conventional aircraft has reached a point of saturation, novel configurations are required for coping with increased operational demands for airliners and stringent environmental requirements for the future. In the search for such configurations, old ideas like the Blended wing Body (BWB) seem to readily provide attractive solutions. However, for successful application of the BWB configuration, a major problem must be solved: the design of a rotationally non-symmetric fuselage with a reasonable weight. This paper outlines the search for the optimal fuselage. Beginning with a short historical overview and a presentation of future demands, the concept of multidisciplinary design, together with simple design rules, is enabled for crystallising the optimal anisotropic multi bubble fuselage arrangement.