Circadian patterns of cardiovascular vulnerability have been well documented, with a peak incidence of cardiovascular events in the morning. Recent studies have outlined the importance of the “Clock genes” in the development of metabolic disorders predisposing to atherosclerosis. Rev-erbα is a nuclear receptor that regulates hepatic and adipose lipid metabolism as well as vascular inflammation. Recent findings identify Rev-erbα also as a major regulator of the circadian regulation of metabolic pathways. Moreover, cross-talk between Rev-erbα and other nuclear receptors well described as key regulators of atherosclerosis may converge to integrate metabolic and circadian signals.