Using a functional genomic approach, we have recently shown that the orphan nuclear receptors ERRα and γ coordinate a broad transcriptional program controlling energy production and utilization in the heart. In addition, both ERRs appear to be critical for normal heart function as several of their target genes are known to be associated with human cardiomyopathies. The ability to regulate the activity of ERRα and/or ERRγ using synthetic ligands suggests the potential for new therapeutic approaches to prevent and manage cardiovascular diseases.
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
Tel.: +1 703 830 6300
Fax: +1 703 830 2300 firstname.lastname@example.org
(Corporate matters and books only) IOS Press c/o Accucoms US, Inc.
For North America Sales and Customer Service
West Point Commons
Lansdale PA 19446
Tel.: +1 866 855 8967
Fax: +1 215 660 5042 email@example.com