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Dysfunction of frontal circuits may underly impaired cognition in schizophrenia. Impaired cognitive control in schizophrenia may be related to altered function of anterior cingulate cortex and DLPFC. Neuro-imaging studies confirm that deficits in DLPFC are marked at the first episode, while ACC deficits are evident in chronic patients. Cognitive disability in schizophrenia evidenced by fMRI and high density ERP may help to elucidate mechanistic account of schizophrenia and to accelerate drug discovery.
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