The Grid and agent communities both develop concepts and mechanisms for open distributed systems, albeit from different perspectives. The Grid community has historically focused on “brawn”: infrastructure, tools, and applications for reliable and secure resource sharing within dynamic and geographically distributed virtual organizations. In contrast, the agent's community has focused on “brain”: autonomous problem solvers that can act flexibly in uncertain and dynamic environments. Yet as the scale and ambition of both Grid and agent deployments increase, we see a convergence of interests, with agent systems requiring robust infrastructure and Grid systems requiring autonomous, flexible behaviors. Motivated by this convergence of interests, we review the current state of the art in both areas, review the challenges that concern the two communities, and propose research and technology development activities that can allow for mutually supportive efforts.