Virtual reality (VR) driving simulators may be used as an aid to traditional cognitive-behavioral therapy in the treatment of a variety of driving-related disorders. In recent years there has been a heightened interest among researchers and clinicians in using VR technology to address a wide range of driving-related issues. Clinical applications include specific driving phobias, driving phobias related to panic and agoraphobia, and posttraumatic stress disorder (PTSD) as a result of motor vehicle accidents. Other areas of interest include neurorehabilitation for individuals who have sustained various brain injuries, examining the impact of pharmaceuticals while driving, and assessing and predicting driving abilities among teenage and elderly populations. The VR world elicits real reactions that can be modified through therapy to help people overcome disorders and traumas such as these. As with any type of treatment, some limitations exist. However, results thus far have been promising and directions for future research are discussed.